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KMID : 0438219740110020973
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Korea University Medical Journal
1974 Volume.11 No. 2 p.973 ~ p.986
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The Influence of Phenylephrine and Pilocarpine on the Histopathological Changes of Distant Organs due to Nasal Reflex
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Abstract
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Phenylephrine and pilocarpine are well known as those of the stimulating drugs on the autonomic nervous system. Author investigated the histopathological changes of the lung, liver, kidney and adrenal gland after electrocauterization to the nasal septum of rabbits pretreated with phenylephrine and pilocarpine injections intramusculary.
The stimuli and injection given were as follows:
A. Control group(electrocautery group)
Electrocauterization was performed with hyfrecator on the anteroinferior portion of nasal septum for 3 seconds.
B. Phenylephrine group
1) Intramuscular injecting group
0.04% phenylephrine hydrochloride solution was injected into the buttock of rabbits.
2) Septal stimulating group after intramuscular injection. Electrocauterization of nasal septum after 0.04% phenylephrine hydrochloride injection into the buttock of rabbits.
Pilocarpine group
1) Intramuscular injecting group
0.1% pilocarpine hydrochloride solution was injected into the buttock of rabbits.
2) Septal stimulating group after intramuscular injection. Electrocauterization of nasal septum after 0.1% pilocarpine hydrochloride injectign into the buttock of rabbits.
Experimental animals were sacrificed immediately, 1 hour and 3 hours later respectively after septal stimulation. Specimens were obtained for microscopic examination from lung, liver, kidney and adrenal gland, and stained with H-E solutions.
The result obtained were;
1. Electrocauterization to the anteroinferior site of mucous membrane of left nasal septum brought capillary congestions in lung, liver, kidney and adrenal gland.
2. In phenylephrine group; Septal stimulating group after phenylephrine injection did not show much difference in histopathological changes of distant organs than the control group except in Lung and liver.
3. In pilocarpine group; Septal stimulating group after pilocarpine injection did not show any difference
in histopathological changes of distant organs than the control group except in Lung and liver.
It seems that there is no synergic action at distant organs between pharmacological stimulation on the peripheral autonomic nerve and septal stimulation. Author suggest that histopathological changes in distant organs due to nasal reflex may occur by more complicated and delicate mechanisms in peripheral.
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